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This is a stripped-down lightweight version of Seurat's internal function adapted for an anndata object that has genes in columns not rows.

Usage

PseudoBulkExpression2(
  object,
  pb.method = "average",
  features = NULL,
  group.by = "ident"
)

Arguments

object

anndata object

pb.method

pseudo-bulk method. Can be 'average' (default) or 'aggregate'.

features

features to analyze. Default is all features in the object

group.by

metadata column to group cells by

Value

matrix with pseudo-bulk counts